| Abstract |
Dr. Atwood has sought to define the role
of chemokine receptors in mediating infection of glial cells
by T-cell, macrophage, and dual tropic strains of HIV-1. He
has also sought to define the mechanism of infection of astrocytes
by HIV-1. Dr Atwood and his laboratory have demonstrated that
the low efficiency of astrocyte infection by HIV-1 is due
to inefficient viral entry in the absence of the prototypical
receptors. He has postulated that the identification of the
mechanism of infection in this cell line may lead to the development
of reagents useful in identifying astrocytes in vivo which
may harbor HIV genomes. He has successfully secured NIH funding
as a co-investigator (P20 RR015578).
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