MIDAS Project Publication Abstracts
Rothschild, L., Zimmerman, M. Borderline personality
disorder and age of onset in major depression. Journal of Personality
Disorders, 2005, 16, 189-199.
In the present report from the Rhode Island Methods to Improve
Diagnostic Assessment and Services (MIDAS) project we tested the
hypothesis that borderline personality disorder (BPD) accounts for
the observed differences between early and late onset major depressive
disorder (MDD). Four hundred and forty depressed outpatients were
evaluated with semi-structured interviews. Patients were subdivided
by age of onset and the presence or absence of comorbid BPD. The
overall pattern of clinical and demographic variables differed,
and two separate multiple logistic regression analyses addressed
the association between age of onset and BPD in MDD patients. Comorbid
BPD was not significant in the multivariable age of onset equation,
and the results of the multivariable analyses support the idea of
difference between subtypes. It is concluded that although early
age of onset is predictive of BPD, BPD is not a universal feature
of early-onset MDD.
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