Diabetes Treatment:
Oral Prescription Medications

Oral medications are sometimes used to lower blood sugar in persons with Type D diabetes (non-insulin dependent diabetes mellitus). Medications are recommended for people with Type D diabetes whose blood sugar is not controlled by diet and exercise alone.

These medications can be referred to as oral agents, diabetes pills, anti-diabetic agents, plus special trade or generic names. All of these medications require a doctor's prescription. They differ in dosage and length of action. It is important to note that they are not an oral form of insulin, nor do they replace insulin.

How do they lower blood sugar?

Prescription medications can lower blood sugar by:

  • Causing the body to release more insulin into the blood stream, or
  • Helping the body to use its own insulin more effectively.

These pills cannot work alone to lower blood sugar. They are part of the treatment plan which includes diet, exercise, education and self-testing of blood sugar.

When should these medications be taken?

Each medication will have its own instructions. Some of the more common diabetes medications are listed below. If your physician has recommended a different protocol, please follow his/her advice.

  • Glipizide (Glucotrol, Glucotrol XL): take 20 minutes before a meal
  • Glyburide (Micronase, DiaBeta, Glynase): take before or after a meal
  • Metformin (glucophage): take with food in the stomach or after a meal

Some people take these medications once a day, while others take the dose more than once a day. You should take your dose at the same time each day to keep the blood sugar in good control. Do not skip a dose; this could cause your blood sugar level to go higher than normal.

When not in use, most oral diabetes medications should be kept at room temperature and out of the reach of children.

Possible side effects

All medications may produce some side effects. Prescription medications used to treat diabetes can abnormally lower your blood sugar. Diabetics should always carry a sugar source (i.e., candy, glucose tablets) with them to treat a low blood sugar reaction.

The most common side effects of these medications are: 

  • upset stomach
  • diarrhea
  • nausea
  • skin rash (not as common)

Report any of these side effects to your doctor. Using alcohol with these medications can increase the risk of side effects.

Of special note: With metformin, report the onset of any new stomach or intestinal symptoms, or any changes in mental state, such as confusion or "fogginess." If you take metformin and are having an x-ray that requires dye, check with your doctor; many times the medicine is stopped for 48 hours before and after the test.

Who shouldn't take these drugs?

  • These medications will not work in a person with Type I diabetes whose body is no longer making insulin. 
  • Pregnant women should not use them.
  • People with kidney or liver disease should consult their physician before starting diabetes medication.

 

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