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Lifespan’s A - Z Health Information Library |
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Febrile/cold agglutininsDefinitionAgglutinins are antibodies that cause the red blood cells to clump together.
This article discusses the blood test used to measure the level of these antibodies in the blood. Alternative NamesCold agglutinins; Weil-Felix reaction; Widal's test; Warm agglutinins How the Test is PerformedBlood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood. Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. (The tube is first warmed to normal body temperature - 98.6 degrees F). The elastic band is removed from your arm. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding. In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding. The sample is sent to a laboratory. How to Prepare for the TestThere is no special preparation. How the Test Will FeelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing. Why the Test is PerformedThis test is done to diagnose certain infections and to determine the cause of hemolytic anemia. Distinguishing between warm and cold agglutinins can help understand why the hemolytic anemia is occurring and can direct therapy. Normal Results
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results. What Abnormal Results MeanThe presence of warm agglutinins may occur with:
The presence of cold agglutinins may occur with:
RisksVeins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others. Other risks associated with having blood drawn are slight but may include:
ConsiderationsIf cold agglutinin disease is suspected, the individual needs to be kept warm. ReferencesSchwartz RS. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 164. Baum SG. Mycoplasma infections. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 338. Review Date: 11/2/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc. The information provided herein should not be used during any
medical emergency or for the diagnosis or treatment of any medical
condition. A licensed medical professional should be consulted for
diagnosis and treatment of any and all medical conditions. Call 911
for all medical emergencies. Links to other sites are provided for
information only -- they do not constitute endorsements of those
other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the
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