Comprehensive Cancer Center physicians and researchers are actively involved in clinical trials that range from large, nationwide studies to small, innovative trials of new
treatments. Patients have access to promising, new treatments through participation in these cancer trials. Comprehensive Cancer Center physicians
participate in the Brown University Oncology Group (BrUOG), a unique regional clinical trials network that provides highly innovative approaches to cancer
Rhode Island Hospital has received several Center of Biomedical Research Excellence (COBRE) grants from the National Center for Research Resources (NCRR)
of the National Institutes of Health, recognizing its pivotal role in cancer research.
One COBRE grant provided funding for the development of a major stem cell research center at Rhode Island Hospital, which is conducting research to study
basic stem cell biology and identify unique approaches to tissue regeneration in lung and marrow diseases. The researchers’ goal is to translate basic stem
cell studies into clinical trials on tissue restoration or correction in patients with chronic obstructive lung disease and malignant blood diseases.
Another COBRE grant funded the establishment of the Center for Cancer Research Development (CCRD) at Rhode Island Hospital. The mission of the CCRD is to
reduce cancer incidence and mortality in Rhode Island and southeastern Massachusetts through the application of new knowledge obtained during research
studies. The CCRD offers cancer researchers access to the latest technologies in molecular pathology and the emerging field of proteomics, which refers to
efforts to identify and quantify proteins with the goal of determining how they interact, how their expression changes by disease, and how they are
modified by environmental change. Researchers analyze changes in protein expression profiles that occur when normal cells become cancerous, and study
molecular and cellular events involved in the development of cancer. The goal is to translate research discoveries into more effective methods for the
treatment of patients with cancer.