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  • GI Protocols

  • Colorectal Cancer

    1. CALGB 80702:  A Phase III Trial of 6 versus 12 Treatments of Adjuvant FOLFOX plus Celecoxib or Placebo for Patients with Resected Stage III Colon Cancer
      PI: William Sikov, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    2. BRUOG 254: A Dose Finding Study of Eribulin Mesylate and Cetuximab For Patients With Advanced Head and Neck and Colon Cancer With an Expansion Cohort For Head and Neck Cancer: A Brown University Oncology Research Group Study
      PI: Howard Safran, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    3. ACCRU MORAb: A Randomized, Double-blind, Placebo-controlled Study of the Efficacy and Safety of Monotherapy MORAb-004 Plus Best Supportive Care in Subjects with Chemorefractory Metastatic Colorectal Cancer
      PI: Howard Safran, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    4. BrUOG CR-261: Single Agent Adjuvant Aflibercept (ziv-Aflibercept) for Patients with Resected or Ablated Metastatic Colorectal Cancer: A Randomized Phase II Study
      PI: Howard Safran, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    Esophageal Cancer

    1. RTOG 1010: A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of HER2-Overexpressing Esophageal Adenocarcinoma
      PI: Howard Safran, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    2. CALGB 80803: Randomized Phase II Trial of PET Scan-Directed Combined Modality Therapy in Esophageal Cancer
      PI: Kimberly Perez, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    Pancreas Cancer

    1. RTOG 0848: A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma
      PI: Howard Safran, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    2. BrUOG P-278 - FOLFOX-A For Pancreatic Cancer: A Brown University Oncology Research Group Study
      PI: Howard Safran, MD
      Sites: Rhode Island Hospital, The Miriam Hospital

    Liver Cancer

    1. LS-P-BRISK TA: A Randomized, Double-blind, Multicenter Phase III Study of Brivanib versus Placebo as Adjuvant Therapy to Trans-Arterial Chemo-Embolization (TACE) in Patients with Unresectable Hepatocellular Carcinoma: The BRISK TA Study
      PI: Howard Safran, MD
      Sites: Rhode Island Hospital, The Miriam Hospital