 Jorge E. Albina, MD
Universidad Nacional La Plata, Argentina, 1972
Rhode Island Hospital, Department of Surgery
Nursing Arts, Rm. 216
Jorge_Albina@brown.edu
Research Interests
Successful wound healing requires the coordinated activities of multiple cell types that constitute the inflammatory and reparative response to tissue injury. The identification of growth factors, cytokines, matrix components and other products present in the wound promises clinical applications that will allow active therapeutic intervention. Development of these applications will require a better understanding of the biology of inflammatory cells, most specifically as it relates to modulation by the wound environment.
The laboratory has recently focused its attention on the early events that follow tissue injury. In this regard, the temporal kinetics and cellular basis for the expression of nitric oxide synthase in the wound were characterized, along with the effects of NO production by wound cells on inflammatory cell function. Moreover, recent results challenge the current paradigm regarding the resolution of acute inflammation by demonstrating that wound macrophages actively induce apoptosis in wound neutrophils, using for this purpose a constitutive effector system comprising beta-3 integrins and membrane-bound tumor necrosis factor-alpha.
Selected Publications
Meszaros A.J., Reichner J.S., Albina J.E. Macrophage phagocytosis of wound neutrophils. J Leukoc. Biol. 65(1):35-42,1999.
Albina J.E., Mastrofrancesco B, Reichner, J.S. Acyl phosphatase activity of NO-inhibited glyceraldehyde-3-phosphate dehydrogenase (GAPDH): a potential mechanism for uncoupling glycolysis from ATP generation in NO-producing cells. Biochem J. 341:5-9, 1999.
Nessel C.C., Henry W.L., Jr., Mastrofrancesco, B., Reichner, J.S., Albina, J.E. Vestigial respiratory burst activity in wound macrophages. Amer. J. Physiol. 276:R1587-94, 1999.
Reichner, J.S., Meszaros, A.J., Louis, C.A., Henry, W.L., Jr, Mastrofrancesco B., Martin B-A. & Albina J.E. Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds. Amer. J. Pathol. 154:1097-104, 1999.
Louis C.A., Mody V., Henry W.L., Jr, Reichner J.S., Albina J.E. Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages. Amer. J. Physiol. 276:R237-42, 1999. |
