Proteomics Specialized Equipment and Capability
Detailed
Summary
of the
Ciphergen
ProteinChip
Series 4000
1) Superior quantization
- Raster laser design for maximum spot coverage
- Auto laser energy setting
- Allows for standardization and efficient optimization of protocols
- Focused troubleshooting
- Improved ProteinChip Arrays and protocols
2) Enhanced Sensitivity
- New high sensitivity detector
- Average peptide mass has higher accuracy for peptide mapping
- Sharper peak resolution to distinguish individual masses
- Sharper resolution of high mass proteins
- Highest dynamic range
- Able to resolve individual masses up to 300 kDa
- Only system currently able to resolve peaks from high molecular mass proteins
- New Ion Source increases ion efficiency
- New patented detector blanking reduces noise
- Eliminates detector saturation from off scale signals such as that from the Energy Absorbing Matrix.
- Innovative flight tube design
- Improves sensitivity by minimizing loss of ions as they travel the detector
- Ions are focused resulting in excellent resolution for peptide maps for protein identification
3) Increased resolving power
- Improved fractionation tools
- Increased resolution of up to 3000 proteins
- Biomarker Pathways
- Protein interaction pathway discovery and quantitative assays
- Improved quantization
- Develop assays with broad dynamic range.
- Measure low and high abundant proteins within the same sample.
- Raster laser design
- Maximum spot coverage and total desorption of the sample
- Improved detection of low abundant proteins.
Detailed Summary of the improved capabilities offered by the new CiphergenExpress Data Manager Software and CiphergenExpress Biomarker Analysis Module
- CiphergenExpress Data Manager Software
- Robust, client-server database centralizes data
- Relational database ensures data integrity
- Intuitive graphical user interface provides ease of use
- Automated tracking of samples, processing protocols, and spectra provides increased efficiency in spectrum annotation
- Required to run Ciphergen Biomarker Analysis Module
- CiphergenExpress Biomarker Analysis Module
- Advanced data handling capabilities provide powerful data management and processing capabilities
- Powerful multivariate methods provide rapid analysis and comparison of multiple mass spectra to help identify biomarkers
- Scalable architecture enables tracking and analysis of large numbers of spectra
One Hoppin Street • Providence, RI 02903
Phone: 401-444-7237 • email: AGarcia3@lifespan.org |
