Hallett Center for Diabetes and Endocrinology
Leslie J. DeGroot, MD
- Professor of Medicine (Research), Division of Endocrinology,
Warren Alpert Medical School of Brown University
Leslie J. DeGroot, MD, joined the division of endocrinology
as a member of the research faculty in 2005. DeGroot served on the
faculty at the University of Chicago for more than three decades.
He trained at Columbia College of Physicians and Surgeons, and did
his residency at New York-Presbyterian Hospital in New York City
and Massachusetts General Hospital in Boston. He served in the Public
Health Service at the National Institutes of Health (NIH) and in
Afghanistan, and spent 12 years at Massachusetts General Hospital
and the Massachusetts Institute of Technology before joining the
department of medicine at the University of Chicago. At the University
of Chicago he was the head of the thyroid study unit, and for many
years head of the endocrine section.
His research interests have recently centered on viral mediated
gene therapy for thyroid cancer, and genetic mechanisms promoting
autoimmune thyroid disease, the subject of his current NIH grant.
Research accomplishments include purification of thyroid peroxidase
and identifying it as the typical antigen in thyroid autoimmunity,
recognition of the thyroid hormone resistance syndrome and cloning
the mutated receptor genes involved, identification of the CTLA-4
gene as a common contributor to many human autoimmune diseases,
development of an adenoviral vector for therapy of medullary thyroid
cancer, and numerous studies on therapy of thyroid cancer. DeGroot
is editor of the three-volume textbook Endocrinology, now
in its fifth edition. He also directs two Web sites, www.endotext.org
and www.thyroidmanager.org,
which present freely available endocrine textbooks for medical doctors
around the world.
Representative Publications
- Takeda, T, Inaba H, Yamazaki M, Kyo S, Miyamoto T, Suzuki S,
Ehara T, Kakizawa T, Hara M, DeGroot LJ, Hashizume K. Tumor-specific
gene therapy for undifferentiated thyroid carcinoma utilizing
the telomerase reverse transcriptase promoter. J Clin Endocrinol
Metab 88:3531-3538, 2003.
- DeGroot LJ. Nonthyroidal illness syndrome is functional central
hypothyroidism, and if severe, hormone replacement is appropriate
in light of present knowledge. J Endocrinol Invest 26:1163-1170,
2003.
- Yamazaki M, Straus FH, Messina M, Robinson BG, Takeda T, Hashizume
K, DeGroot LJ. Adenovirus-mediated tumor-specific combined gene
therapy using Herpes simplex virus thymidine/ganciclovir system
and murine interleukin-12 induces antitumor activity against medullary
thyroid carcinoma. Cancer Gene Therapy, 11:8-15, 2004.
- DeGroot LJ, Zhang R. Viral mediated gene therapy for management
of metastatic thyroid carcinoma. In: Current Drug Targets,
Smallridge RC, editor, Bentham Science Publishers, in press for
2004.
Meet the team
Back |
More about the Hallett Center
|
