Current Active Grants

Prevention of Postpartum Weight Retention

The primary goal of this project is to test the effects of a behavioral lifestyle intervention in promoting healthy weight gain during pregnancy and preventing postpartum weight retention.

Principal Investigator: Rena R. Wing, PhD

Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases

Dates: 2006 - 2010


The Look AHEAD Continuation: Action for Health in Diabetes

Look AHEAD is a randomized clinical trial examining the long-term health effects of an intensive weight loss intervention in approximately 5,145 overweight volunteers with type 2 diabetes. Participants are randomized to an intensive lifestyle intervention designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity, or to a control program of diabetes support and education. The primary outcome of Look AHEAD is the aggregate occurrence of severe cardiovascular events (fatal and non-fatal Ml and stroke and cardiovascular deaths) over a planned follow-up of 11.5 years. The continuation of this project allows for completion of follow up outcome assessments and the continued administration of the lifestyle intervention. These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. (5U01DK056992-11)

Principal Investigator: Rena R. Wing, PhD

Co-Investigators: Vincent Pera, MD; Jeanne McCaffery, PhD

Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Nursing Research

Dates: 1999 - 2013


Gene X Behavioral Interaction in the Look AHEAD Study

The primary goal of this grant is to identify genetic markers that interact with behavioral weight loss treatment to predict the extent of weight loss.

Principal Investigator: Rena R. Wing, PhD; Jeanne McCaffery, PhD

Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases

Dates: 2009 - 2013


Prevention of Weight Gain in Young Adults

"STOP (Study toPrevent) Weight Gain" is a randomized clinical trial testing two innovative interventions to prevent weight gain over an average 3 years of follow-up in individuals 18 to 35 years of age. This study will compare these interventions to each other and to a control condition in a 3-armed randomized controlled clinical trial.

Principal Investigator: Rena R. Wing, PhD

Co-Investigators: Jessica LaRose, PhD; Jeanne McCaffery, PhD

Funding Agency: National Heart, Lung, and Blood Institute

Dates: 2009 - 2014


Lifestyle Intervention to Treat Erectile Dysfunction (LITE)

The purpose of this planning grant is to plan a randomized clinical trial to test the efficacy of lifestyle intervention in obese men with erectile dysfunction.

Principal Investigator: Rena R. Wing, PhD

Co-Investigator: Dale Bond, PhD

Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases

Dates: 2009 - 2011


Innovative Technology to Improve Patient Adherence to Weight Loss Recommendations

The purpose of this project is to use innovative technology to improve adherence to behavioral weight loss strategies.

Principal Investigator: Rena R. Wing, PhD

Co-Investigators: Graham Thomas, PhD

Funding Agency: National Heart, Lung, and Blood Institute

Dates: 2009 - 2011


Increasing Sleep Duration: A Novel Approach to Weight

This project, which establishes the Center for Behavioral Intervention Development (CBID), seeks to translate the basic science on sleep duration into a novel intervention to reduce obesity and obesity-related co- morbidities. The project involves a programmatic series of studies to develop a sleep and weight loss intervention. The target population for these studies will be young adults (age 25 - 45) where the association between sleep duration and obesity appears strongest, who are overweight or obese (BMI 25 - 40), and who currently sleep less than six and a half hours per night. This series of studies will be used to examine the effects of increases in sleep duration alone and in combination with a weight loss program on eating and exercise behaviors (measured objectively), and ultimately on body weight. The effects of increasing sleep duration on physiological, psychological and cognitive changes that may relate to the changes in eating and activity and adherence to weight control recommendations will also be examined. The CBID creates a new interdisciplinary team, including investigators in the areas of behavioral weight control, basic and clinical aspects of sleep, fMRI and neuropsychological assessment of cognitive function, eating and exercise behavior, and physiological changes associated with sleep and weight. (U01 CA150387-01)

Principal Investigator: Rena R. Wing, PhD

Co-Investigators: Dale Bond, PhD; Mary Carskadon, PhD; Robert Considine, PhD; Ron Cohen, PhD; Joseph Fava, PhD; Chantelle Hart, PhD; Jeanne McCaffery, PhD; Richard Millman, MD; George Papandonatos, PhD; Donn Posner, PhD; Hollie Raynor, PhD; Katherine Sharkey, MD; and Larry Sweet, PhD

Funding Agency: National Cancer Institute

Dates: 2009 - 2014