Neurorestoration

Disease and injuries can sever connections within the brain and between the brain and the body, which can impair movement, sensation, cognition and, sometimes, emotion. Restoring lost function in the brain and nervous system with leading-edge technologies and new rehabilitation methods sits at the heart of the work in neurorestoration.

Research and clinical care in this center focus on the causes of, and treatments for, stroke, ALS, trauma – including spinal cord injury and traumatic brain injury – post-traumatic stress disorder, and psychiatric diseases such as depression and obsessive compulsive disorder.

Institute researchers are pursuing projects that include:

The world's first human trials for a brain-machine interface for paralysis  
Optogenetic technologies for diagnosing and treating epilepsy  
Clinical trials developing treatments for conversion disorders  
Cellular and molecular mechanisms for traumatic brain injury  
Biomarkers for mild traumatic brain injury  
Biomarkers for post-traumatic stress disorder and new rehabilitation strategies for veterans  
Mechanisms of epileptic seizures in brain circuits and cells  
Clinical trials for deep brain stimulation for depression and obsessive compulsive disorder  
New neuro-recording and stimulation techniques to understand the mechanisms of learning and decision-making  
Applying new MRI techniques to investigate mild traumatic brain injury  
Biomarkers and therapies for chronic pain  

Team

  • Wael Asaad, MD, PhD, neurosurgeon, Rhode Island Hospital; assistant professor of neurosurgery, The Warren Alpert Medical School of Brown University

  • Linda Carpenter, MD, chief, Mood Disorders Program, Butler Hospital; associate professor of research in the Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University

  • Joanna Szmydynger-Chodobska, PhD, co-director, Neurotrauma and Brain Barrier Research Laboratory at Rhode Island Hospital; assistant professor, Department of Emergency Medicine, The Warren Alpert Medical School of Brown University

  • Adam Chodobski, PhD, co-director, Neurotrauma and Brain Barrier Research Laboratory at Rhode Island Hospital; associate professor, Department of Emergency Medicine, The Warren Alpert Medical School of Brown University

  • Barry Connors, professor and chair, department of Neuroscience, Brown University

  • Joseph Crisco, PhD, director, Biomechanics Laboratory, Rhode Island Hospital; professor in the Department of Orthopedics, The Warren Alpert Medical School of Brown University

  • John Donoghue, PhD, Henry Merrit Wriston Professor and professor, Department of Neuroscience, Brown University; director, Brown Institute for Brain Science

  • Christian Franck, PhD, assistant professor, School of Engineering, Brown University

  • Benjamin Greenberg, MD, PhD, chief of outpatient services, Butler Hospital; associate professor, Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University

  • Leigh Hochberg, MD, PhD, attending physician, Massachusetts General Hospital, Brigham and Women’s Hospital; physician, Center for Restorative and Regenerative Medicine, Providence VA Medical Center; associate professor, School of Engineering, Brown University

  • Gregory Jay, MD, attending physician, Rhode Island Hospital; director of research and professor in the Department of Emergency Medicine, The Warren Alpert Medical School of Brown University

  • W. Curt LaFrance Jr, MD, MPH, director of neuropsychiatry and behavioral neurology at Rhode Island Hospital, and assistant professor of psychiatry and neurology (research), The Warren Alpert Medical School of Brown University

  • Al Lo, MD, PhD, CPH, associate professor of Neurology and associate professor of Epidemiology, Brown University

  • Christopher I. Moore, PhD, associate professor of systems neuroscience, Brown Institute for Brain Science

  • Arto Nurmikko, PhD, professor of physics and engineering, School of Engineering, Brown University 

  • Noah Philip, MD, assistant professor, Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University; staff psychologist and neuromodulation fellow, Butler Hospital

  • Steven Rasmussen, MD, medical director, Butler Hospital; interim chair, Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University

  • Carl Saab, PhD, assistant professor, department of neurosurgery Rhode Island Hospital, department of neuroscience, Brown University 

  • Audrey Tyrka, MD, PhD, director, Laboratory of Clinical and Translational Neurosciences, Butler Hospital; assistant professor in the Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University