Norman Prince Neurosciences Institute

Core Facilities

Hospital-Imaging Research and Education Service (HI-RES)

The hospital-imaging research and education service (HI-RES) was established in 2014 as a core service supporting the growth of imaging research and education among hospital-based staff.

HI-RES is a joint-venture with the Norman Prince Neurosciences Institute (NPNI) and the departments of neurology, neurosurgery, psychiatry and diagnostic imaging at The Warren Alpert Medical School of Brown University. HI-RES serves both the Lifespan (Rhode Island, The Miriam, Hasbro Children’s, Bradley and Newport hospitals) and Care New England (Butler, Women and Infants, and Kent County hospitals) healthcare systems as well as the Providence VA Medical Center.

Learn more about HI-RES

Quantitative Sciences Program

The quantitative sciences program (QSP) provides training in the form of formal workshops, seminars and individual mentoring in the areas of quantitative methodology, including research and experimental design, survey and sampling methods, basic and advanced multivariate data analysis.

The QSP is supported by participation in research projects and by the Norman Prince Neurosciences Institute and the departments of neurology and psychiatry/human behavior. It collaborates with researchers at Brown University and affiliated hospitals and across the nation.

Learn more about the quantitative sciences program

Norman Prince Cellular and Molecular Neuroscience Core

This core facility is designed to support investigators involved in clinical and translational research in the neurosciences and is available to all researchers in the Norman Prince Neurosciences Institute and the Brown Institute for Brain Science. The laboratory provides a broad menu of testing, coordinated with the Lifespan Core Laboratories and the Molecular Pathology Core Laboratories. By providing access to common testing, the NPNI encourages cross-disciplinary fertilization to better understand pathogenesis of human neurologic disease.

Physician-scientists at Lifespan and Brown University are working to uncover novel targets for diagnosis, treatment, and monitoring disease and its progression. Research efforts by experienced faculty in Neuropathology, Neurology, Neurosurgery, and Neuroradiology are underway, with investigators in each area cooperating in the use of molecular and cellular diagnostics.

Our primary goal is to assist investigators engaged in human or experimental disease model research. Major research topics serviced by the Core include:

  1. Neurodegeneration;  
  2. Primary malignant CNS neoplasia;
  3. Inflammatory and autoimmune demyelinating diseases;
  4. Perinatal hypoxic-ischemic leukoencephalopathy;
  5. Cerebrovascular disease including ischemia-reperfusion injury and CADASIL;
  6. Diabetes and hypertension associated cerebral microvascular disease;
  7. Normal pressure hydrocephalus;
  8. HIV;
  9. Metabolic encephalopathies;
  10. Traumatic brain injury;
  11. Neuromuscular diseases, and
  12. Blood-brain barrier disruption.

Learn more about the cellular and molecular neuroscience core