RI Hospital joins elite nationwide research network

November 28, 2017

Rhode Island Hospital has joined a cadre of other elite medical centers nationally serving as hubs for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The network facilitates improved coordination and sharing of lifesaving emergency medicine research around the treatment of gravely serious conditions, such as traumatic brain injury, cardiopulmonary arrest, and sepsis.

Nationally, the network is composed of 11 hubs, each consisting of a group of hospitals. Rhode Island Hospital and its academic affiliate The Warren Alpert Medical School of Brown University lead a group that includes the emergency services of Rhode Island Hospital’s pediatric division, Hasbro Children’s Hospital, The Miriam Hospital, Newport Hospital, Women & Infants Hospital, and the R Adams Cowley Shock Trauma Center in Baltimore, Maryland.

The project is led by principal investigator Lisa H. Merck, M.D., M.P.H., an emergency medicine attending physician at Rhode Island Hospital and director of the Division of Emergency Neurosciences at Brown University’s Alpert Medical School.

The Rhode Island Hospital SIREN hub has also entered into a five-year agreement to form a “superhub” within the SIREN network, known as the COalition for REsearch in Emergency Medicine (CORE-EM Alliance). The alliance includes five other leading emergency medicine research centers: Emory University, Tufts University, University of Arizona, University of Texas Health Science Center at Houston, and Orlando Regional Medical Center. The CORE-EM Alliance is composed of 23 Level I trauma centers and serves an encatchment area of approximately 53 million patients.

“The CORE-EM Alliance is a collaborative effort to advance research in resuscitative medicine. We are excited to partner with other leading research centers to further advance the work of the SIREN network,” said Merck. “These centers cover a substantial portion of the eastern seaboard and southeast. Individually, each center will bring a great deal of expertise to the collaboration and together, CORE-EM will serve a large, diverse patient population. Our combined numbers and collaborative expertise will enable us to contribute in a meaningful way to advancing research in resuscitative medicine.”

CORE-EM will be joining SIREN to conduct several large-scale studies of 1,000-plus patients over the next five years. Each of the six hubs within the CORE-EM Alliance is affiliated with multiple hospitals. The model is flexible and efficient, with the ability to transition seamlessly from six independent research centers, up to 30-plus enrolling hospital sites.

Christina Spaight O'Reilly

Rhode Island Hospital