Lifespan Cardiovascular Institute

RenalGuard Trial Patient

Patients who have impaired kidney function and are scheduled to undergo a catheterization procedure may be eligible for this research study. The purpose of this study is to determine if a new treatment that will match the patient's urine output with the amount of fluid given during the procedure will help to prevent kidney damage. This is called induced diuresis with matched hydration and potentially effective way to protect the kidneys during a catheterization procedure.

The way that matched hydration therapy is done is by making the kidneys produce more urine than usual (before, during, and immediately after the procedure), then matching the amount of urine produced by replacing it with the same volume of a standard, sterile salt solution (saline). The saline is infused via a small intravenous (IV) catheter that is placed into a vein in the arm.

It is believed that this works by more rapidly flushing the contrast agent out of the body making the kidneys at lower risk for damage. It is also believed that by replacing only the amount of fluid produced from the body during urination, potential side effects from either putting too much or not enough fluid into the body will be prevented.

For more information, please contact:
Cardiovascular Research
The Miriam Hospital
Lori-Ann DeSimone

Rhode Island Hospital
Cardiac Projects Office