Infectious Diseases Clinical Research

Clinical Trials

For more information about clinical trials, please visit www.clinicaltrials.gov or contact us directly:

  • Pamela Poethke, RN, 401-793-4971
  • Karen Tashima, MD, 401-793-4979

To inquire about any of our studies call 401-793-4317 or email IDResearch@lifespan.org.

The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel.

We conduct trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C.

Other studies offered through our clinical trials unit include pharmaceutical studies to treat hepatitis C, prevent C. difficile infection, and test new methods of diagnosing HIV infection.

Currently Enrolling Research Studies

Clinical Studies

5332 REPRIEVE – HIV/Heart Health

Test if pitavastatin can prevent heart disease in HIV positive patients

Key Requirements
  • Ages 40-75
  • Taking HIV medications
  • CD4 count greater than 100
  •  NOT taking a statin
  •  No history of heart disease or stroke

5354 EARLIER – Early HIV Treatment  

Evaluate if early treatment helps the body control HIV better and keep HIV from “hiding” in the body.

Key Requirements
  • Ages 18 years of age or older
  • Willing to start HIV treatment right away  
  • Lab tests to confirm very recent HIV infection​

5324 – HIV and Memory  

Evaluate if adding one of two different FDA-approved HIV meds helps improve brain function.    

Key Requirements
  • Ages 18 years of age or older
  • Currently on HIV medications with undetectable viral load
  • Some problems with memory, focus or daily activities

5336 – HIV Long-Term Effects

Treatment with an FDA-approved drug to determine if it can help with the long-term affects of HIV infection    

Key Requirements
  • Ages 18 years of age or older
  • Currently on HIV medications
  • Have an undetectable viral load for two years
  • CD4 count 350 or greater

Behavioral Studies

Project HIVPASS

Behavioral intervention study

Key Requirements
  • HIV positive adults 18 or older
  • Living with or cured of hepatitis C

Gyenecological Studies

VAST – Vaginal antibody safety test  

Test investigational medication to prevent HIV and genital herpes.

Key Requirements
  • Women ages 18 to 45
  • HIV negative
  • Not pregnant
  • Currently using effective birth control

HIV-1 Reservoir in Female Genital Tract 

Compare HIV reservoir in genital tract to HIV in blood.

Key Requirements
  • Ages 18 and over
  • Still has regular periods
  • Not anemic
  • Group 1: Well controlled on HIV medications                   
  • Group 2: Planning on beginning HIV medications and viral load over 1000 copies

Hormones and HIV Acquisition in HIV Negative Women 

Test whether using hormonal contraception or creams increases risk of HIV infection in women.

Key Requirements
  • Ages 18 years and over
  • HIV negative
  • Regular periods
  • Not anemic
  • Plan on starting on hormonal contraception or hormonal creams

To inquire about any of these studies call 401-793-4317 or email IDResearch@lifespan.org.