Alzheimer's Disease & Memory Disorders Center
Rhode Island Hospital

CREATES Study

An Investigational Study of Post-Operative Cognitive Impairment in Older Adults

Researchers at Rhode Island Hospital, led by research scientist Dr. Lori Daiello, PharmD, ScM, of the Alzheimer’s Disease and Memory Disorders Center (ADMDC) are recruiting for a groundbreaking investigational study funded by the National Institutes on Aging. The study, Blood-Brain Barrier Disruption as a Biomarker for Perioperative Neurocognitive Disorders: Cognitive Recovery after Elective Surgery (CREATES), aims to better understand why some older adults develop long-lasting changes in their memory and thinking abilities after major surgery.

Results of recent research suggest that inflammatory activity after surgery may trigger a cascade of events that can damage brain cells and interfere with normal recovery of brain function.  The CREATES study will expand upon these findings by using a new type of MRI brain imaging technique to investigate whether blood-brain barrier dysfunction may increase the risk of postoperative cognitive problems.

logo for Creates study

More Information

If you are interested in volunteering for the CREATES study or have questions about our research, contact the Rhode Island Hospital ADMDC at 1-833-220-0100 or email CREATES@lifespan.org.

Eligible Participants for the CREATES Study

This study is seeking individuals age 70 years or older who are scheduled to undergo a major orthopedic, vascular or gastrointestinal elective surgery at Rhode Island Hospital or The Miriam Hospital.

If you are undergoing major elective surgery and interested in volunteering for the CREATES study or have questions about our research, contact study staff at 1-833-220-0100 or email CREATES@lifespan.org.