Phase II Projects
Investigator: Ying-jie (Angie) Guan, MD, PhD
Project 1: Mechanosomes Essential for Regulating Chondrocyte Differentiation
Investigator: Anthony M. Reginato, MD, PhD
Project 2: Articular Cartilage Calcification in Osteoarthritis
Investigator: Nicolas Fawzi, PhD
Project 3: Seeds of Protein Aggregation in Inclusion Body Myositis
University of Rhode Island
Pilot Project: A Chemo-chrysotherapy for Rheumatoid Arthritis by Hollow Gold Nanospheres
Aim 1: NIR laser-triggered release of MTX from F-HAuNS-MTX and cytokine absorption by the de-pegylated gold nanoparticles.
Aim 2: Chemo-chrysotherapy for RA treatment by F-HAuNS-MTX. Highlights of research: We have found that the photothermally triggered de-pegylation liberates the surface of the hollow gold nanospheres and subsequently binds pro-inflammatory factors. This property may have potential to provide a photo-chrysotherapy to reduce the extracellular levels of pro-inflammatory proteins in rheumatoid arthritis.