Bradley Campus Research Unit
The Bradley Campus Research Unit, under the direction of Gregory Fritz, MD, is part of the Bradley Hasbro Children's Research Center (BHCRC). Its offices are located in the east wing of the Laufer building on the Bradley Hospital campus in East Providence, RI.
The unit is home to the Pedi-MIND program, The Developmental Disorders Genetics Research Program, Neuroplasticity and Autism Disorder Program and the Health Services Research Program.
The goal of the Pedi-MIND program is to identify biological and behavioral markers of psychiatric illness in children and adolescents in order to improve diagnosis, treatment, and prevention of these conditions. Daniel Dickstein, MD sees patients in the outpatient clinic. For more information and to enroll in a study, please visit Pedi-MIND program.
Daniel Dickstein, MD, is the director of Bradley Hospital's Pediatric Mood, Imaging and Neurodevelopment Program (Pedi-MIND). Board certified in pediatrics, psychiatry, and child/adolescent psychiatry, he is also an associate professor of both psychiatry and human behavior as well as pediatrics at The Warren Alpert Medical School of Brown University.
He was previously an assistant clinical investigator with the pediatric and developmental neuropsychiatry branch at the National Institute of Mental Health (NIMH). Dickstein earned his undergraduate and medical degrees from Brown University, and is a graduate of the school's triple board program, a combined residency in pediatrics, general psychiatry, and child and adolescent psychiatry, that leads to board eligibility in all three specialties after five years of training.
Dickstein leads Bradley's Pedi-MIND research program, which uses brain imaging techniques, including magnetic resonance imaging (MRI) and behavioral measures to identify biological markers of psychiatric illness, including bipolar disorder in children and adolescents. Such markers could help physicians make more accurate diagnoses. Dickstein also treats outpatients at Bradley on a limited basis.
In 2009, Dickstein received a National Institute of Mental Health (NIMH) Bio-behavioral Research Award For Innovative New Scientists (BRAINS Award), one of only seven awarded in the program's inaugural year. Dickstein is the recipient of numerous additional awards, including the NIMH's Richard J. Wyatt, MD, Memorial Fellowship Training Award for outstanding scientific accomplishment, NIMH's Mentor of the Year Award, National Institutes of Health Fellows' Award for Research Excellence, and the American Academy of Child and Adolescent Psychiatry Outstanding Resident Award.
A member of the American Academy of Child and Adolescent Psychiatry, the American Psychiatric Association, and a fellow of the American Academy of Pediatrics, Dickstein has authored more than 30 peer-reviewed articles and book chapters.
Dickstein DP, Treland JE, Snow J, McClure EB, Mehta MS, Towbin KE, Pine DS, Leibenluft E. Neuropsychological Performance In Pediatric Bipolar Disorder. Biological Psychiatry 2004; 55(1): 32-39.
Milham MP, Nugent AC, Drevets WC, Dickstein DP, Leibenluft E, Ernst M, Charney DS, Pine, DS. Selective Reduction in Amygdala Volume in Pediatric Anxiety Disorders: A Voxel-Based Morphometry Investigation. Biological Psychiatry. 2005; 57(9): 961-966.
Dickstein DP, Milham MP, Nugent AC, Drevets WC, Charney DS, Pine DS, Leibenluft E. Fronto-Temporal Alterations in Pediatric Bipolar Disorder: Results of a Voxel-Based Morphometry Study. Archives of General Psychiatry. 2005; 62(7):734-741.
Dickstein DP, Rich BA, Binnstock AB, Pradella AG, Towbin KE, Pine DS, Leibenluft E. Comorbid Anxiety in Phenotypes of Pediatric Bipolar Disorder. J. of Child and Adolescent Psychopharmacology. 2005; 15(4): 534-48.
Dickstein DP, Garvey M, Pradella AG, Greenstein D, Sharp W, Castellanos, FX, Pine DS, Leibenluft E. Neurological Examination Abnormalities in Children with Attention Deficit Hyperactivity Disorder and Bipolar Disorder. Biological Psychiatry. 2005; 58(7): 517-24.
Dickstein DP, Leibenluft E. Emotion Regulation in Children and Adolescents: Boundaries Between Normalcy and Bipolar Disorder. Development and Psychopathology. 2006;18: 1105-1131.
Leibenluft E, Rich BA, Vinton DT, Nelson EE, Fromm SJ, Berghorst LH, Joshi P, Robb A, Schachar RJ, Dickstein DP, McClure EB, Pine DS (2005). Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. Am J. of Psychiatry. 2007 Jan; 164(1): 52-60.
Dickstein DP, Nelson EE, McClure EB, Grimley ME, Knopf LV, Brotman MA, Rich BA, Pine DS, Leibenluft E. Cognitive Flexibility in Phenotypes of Pediatric Bipolar Disorder. J. Am. Acad. Child Adolesc. Psychiatry. 2007 Mar; 46(3): 341-355. PMID:
Dickstein DP, Rich BA, Roberson-Nay R, Berghorst L, Vinton D, Pine DS, Leibenluft E. Neural Activation During Encoding of Emotional Faces in Pediatric Bipolar Disorder.Bipolar Disorders. 2007 Nov; 9(7): 679-92.
Dickstein DP, der Veen JW, Knopf L, Towbin KE, Pine DS, Leibenluft E. Proton magnetic resonance spectroscopy in youth with severe mood dysregulation.Psychiatric Research: Neuroimaging. 2008 May 30; 163(1): 30-9.
Dickstein DP, Towbin KE, der Veen JW, Rich BA, Brotman MA, Knopf L, Onelio L, Pine DS, Leibenluft E. Randomized double-blind placebo-controlled trial of lithium in youth with severe mood dysregulation. J Child and Adolescent Psychopharmacology. J Child Adoles Psychopharmacology. 2009 Feb;19(1): 61-73.
Dickstein DP, Finger EC, Brotman MA, Rich BA, Pine DS, Blair JR, Leibenluft E. Impaired probabilistic reversal learning in youths with mood and anxiety disorders.Psychological Medicine. 2009 Oct 12: 1-12.
Dickstein DP, Gorrostieta C, Ombao H, Goldberg LD, Brazel AC, Gable CJ, Kelly C, Gee DG, Zuo XN, Castellanos FX, Milham MP. Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder. Biol Psychiatry. 2010 Nov 1;68(9):839-46.
Dickstein DP, Finger EC, Skup M, Pine DS, Blair JR, Leibenluft E. Altered neural function in pediatric bipolar disorder during reversal learning. Bipolar Disord. 2010 Nov;12(7):707-19.
Developmental Disorders Genetics Research Program
The Developmental Disorders Genetics Research Program seeks to identify genes associated with autism and intellectual disability so that it can be detected and diagnosed earlier and more accurately and treated more effectively. Eric Morrow, MD, PhD, sees patients on the Bradley campus. His genetics and neuroscience research lab is located at Brown University. For more information or to enroll in a study, please visit the Developmental Disorders Genetics Research Program.
Eric Morrow received his PhD in genetics and neurodevelopment at Harvard University and his medical degree from the Health Science Training Program at MIT and Harvard Medical School.
During this medical training, Dr. Morrow developed a strong interest in the scientific challenges posed by childhood neuropsychiatric disorders. He conducted further clinical and scientific training in neurology and psychiatry at Harvard Medical School.
Dr. Morrow was MGH Rappaport Neuroscience Scholar and Assistant Professor at Harvard Medical School prior to coming to Brown University as assistant professor, department of molecular biology, cell biology and biochemistry.
Most recently, Dr. Morrow was one of 102 recipients of the 2017 Presidential Early Career Award in Science and Engineering—the government’s highest honor for a young scientist. The award was bestowed in recognition of his work on understanding and improving treatments for psychiatric conditions including autism and severe intellectual disability. President Barack Obama said in the announcement, “These innovators are working to help keep the United States on the cutting edge, showing that federal investments in science lead to advancements that expand our knowledge of the world around us and contribute to our economy.”
Neuroplasticity and Autism Disorder Program
The Neuroplasticity and Autism Disorder Program uses electrophysiological techniques to investigate contributors to autism spectrum disorders with the long-term goal of developing novel therapeutic interventions.
Lindsay Oberman received her PhD in experimental psychology at University of California, San Diego in 2007. While in graduate school she used electroencephalography (EEG) and electromyography (EMG) to study the brain basis of social impairments in children with autism spectrum disorders.
Oberman then obtained a mentored postdoctoral fellowship at the Berenson-Allen Center for Noninvasive Brain Stimulation at Harvard Medical School where she developed paradigms using transcranial magnetic stimulation (TMS) to study brain plasticity and excitability in individuals with autism spectrum disorders.
Oberman was an Instructor in the department of neurology at Harvard Medical School with appointments both at Beth Israel Deaconess Medical Center and Children’s Hospital, Boston prior to coming to Bradley Hospital.
Health Services Research Program
The Health Services Research Program focuses on identifying and remediating gaps in the care of young people struggling with mental health and substance use disorders.
Brady Case is a child and adolescent psychiatrist whose focus is identifying and remediating gaps in the care of young people struggling with impairing mental health and substance abuse disorders. A graduate of the Child and Adolescent Psychiatry Fellowship Program of Bradley Hospital and The Warren Alpert Medical School of Brown University, Case most recently served on the faculty of New York University and conducted research for the State of New York. His many honors and awards include the Health Services Research Early Career Award from the American Psychiatric Association, the Laughlin Fellowship from the American College of Psychiatrists, and the Outstanding Resident Award from the National Institute of Mental Health.
Case received his undergraduate degree from Harvard College and his medical degree from Harvard Medical School.
Case recently became one of five child psychiatrists across the U.S. awarded a four-year grant by the American Academy of Child and Adolescent Psychiatry to study adolescent substance use disorders. He is currently collaborating with investigators at Brown University, the National Institutes of Health, Columbia University, New York University and the University of Pennsylvania to advance the care of young people in several core areas:
- More accurately and rapidly identify youth most likely to never receive needed care.
- More effectively extend treatment through new clinical programs and novel policies.
- More rigorously evaluate the effectiveness of treatments currently provided in the community and uncover opportunities for improvement.
- Winickoff JP, Hibberd PL, Case B, Sinha P, Rigotti NA. Child hospitalization: an opportunity for parental smoking intervention. Am J Prev Med 2001;21:218-20.
- Case BG, Himmelstein DU, Woolhandler S. No care for the caregivers: declining health insurance coverage for health personnel and their children, 1988-1998. Am J Pub Health 2002;92:404-8.
- Case BG, Olfson M, Marcus SC, Siegel C. Trends in the inpatient mental health treatment of children and adolescents in U.S. community hospitals, 1990 and 2000. Arch Gen Psychiatry 2007;64:89-96.
- Case BG, Biel MG, Peselow ED, Guardino M. Reliability of personality disorder diagnosis during depression: the contribution of collateral informant reports. Acta Psychiatr Scand 2007;115:487-491.
- Biel MB, Peselow ED, Mulcare L, Case BG, Fieve R. Continuation versus discontinuation of lithium in recurrent bipolar illness: a naturalistic study. Bipolar Disord 2007;9:435-42.
- Choy Y, Peselow ED, Case BG, Pressman MA, Luff JA, Laje G, Paizis M, Ying P, and Guardino M. Three-year medication prophylaxis in panic disorder: to continue or discontinue? A naturalistic study. Compr Psychiatry 2007;48:419-25.
- Pundiak TM, Case BG, Peselow ED, Mulcare L. Discontinuation of maintenance selective serotonin reuptake inhibitor monotherapy after five years of stable response: A naturalistic study. J Clin Psychiatry 2008;69:1811-1817.
- Brodie JD, Case BG, Figueroa E, Dewey SL, Robinson JA, Wanderling JA, Laska EM. Randomized, double-blind, placebo-controlled trial of vigabatrin for treatment of cocaine dependence in Mexican parolees. Am J Psychiatry 2009 2009;166(11):1269-77. Epub 2009 Aug 3.
- Merikangas KR, He JP, Burstein M, Swendsen J, Avenevoli S, Case B, Georgiades K, Heaton L, Swanson S, Olfson M. Service utilization for lifetime mental disorders in U.S. adolescents: results of the National Comorbidity Survey-Adolescent Supplement (NCS-A). J Am Acad Child Adolesc Psychiatry 2011;50:32-45. Epub 2010 Dec 3.
- Siegel CE, Haugland G, Reid-Rose LM, Laska EM, Tang D, Wanderling JA, Chambers ED, Case BG. The Nathan Kline Institute Cultural Competency Assessment Scale: Psychometrics and implications for disparity reduction. Adm Policy Ment Health 201;38:120-30.
- Case BG. Non-adherence: The silent majority. J Am Acad Child Adolesc Psychiatry 2011;50:435-37.[editorial]
Rhode Island Consortium for Autism Research and Treatment (RI-CART)
RI-CART’s mission is to improve the lives of Rhode Islanders with autism spectrum disorders by promoting collaborative, cutting-edge research, improving health care and support services, and providing data-driven education and advocacy. RICART is a collaboration between Bradley Hospital, Women and Infants Hospital, and Brown University. For more information or to enroll in a study, please visit RI-CART.
Stephen Jon Sheinkopf, PhD, has been a psychologist and assistant professor at the Center for Autism and Developmental Disabilities at Bradley Hospital since 2001 and psychologist at the Brown Center for the Study of Children at Risk at Women & Infants Hospital since 2005.
Sheinkopf has also held several university and hospital teaching roles. He has been an assistant professor of Psychiatry and Human Behavior since 2001, and has had a secondary appointment in the Department of Pediatrics at The Warren Alpert Medical School of Brown University since 2008. Sheinkopf has also been a member of faculty at Brown University’s Brown Institute for Brain Science since 2003.
Sheinkopf is a graduate of Tufts University. He earned master’s degrees in psychology and doctoral degree in clinical psychology from the University of Miami. He completed his internship at the Brown University Clinical Psychology Training Consortium, and fellowship training at The Warren Alpert Medical School of Brown University under a National Research Service Award from the National Institute of Health.
Sheinkopf’s research interests include the early identification of autism and developmental disabilities in infancy, development of children at risk, and social and communication development and psychophysiology. He has been principal investigator and co-investigator of several research studies focused on autism and child development.
- Sheinkopf, S. J., Lester, B. M., Sanes, J. N., Eliassen, J. C., Hutchison, E., Seifer, R., LaGasse, L., Durston, S., & Casey, B. J. (2009). Functional MRI and Response Inhibition in Children Exposed to Cocaine In Utero: Preliminary Findings.Developmental Neuroscience, 31, 159-166.
- Sheinkopf, S. J., LaGasse, L. L., Lester, B. L., Liu, J., Seifer, R., Bauer, C. R., Shankaran, S., Bada, H., & Das, A. (2007). Vagal tone as a resilience factor in children with prenatal cocaine exposure. Development and Psychopathology, 19, 649-673.
- Sheinkopf, S. J., Mundy, P., Claussen, A. H., & Willoughby, J. (2004). Infant Joint Attention Skill and Preschool Behavioral Outcomes in At-Risk Children.Development and Psychopathology, 16 (2), 273-291.
- Sheinkopf, S. J., Mundy. P., Oller, D. K., & Steffens, M. (2000). Vocal atypicalities in preverbal autistic children. Journal of Autism and Developmental Disorders, 30, 345-354.
- Sheinkopf, S. J. & Siegel, B. (1998). Home based behavioral treatment of young autistic children. Journal of Autism and Developmental Disorders, 28, 15-23.